Protective Effect of Polyherbal Extract on Gentamicin-Induced Renal Injury in Wistar Rats

This study was carried out to evaluate the protective effects of polyherbal extract against gentamicin induced renal injury in rats. 36 male Wistar rats were divided into six groups. Gentamicin administered (100 mg/kg, intraperitoneally for 10 d) all groups except normal control group. Polyherbal three (gentamicin+polyherbal 100 gentamicin+polyherbal 200 mg/kg and 300 mg/kg) at 100, body weight orally 21 d, respectively. Taurine taken as standard drug given dose rate 50 mg/ kg, d positive The vitro antioxidant activity determined using 2,2-diphenyl- 1-picryl-hydrazyl-hydrate. also subjected phytochemical analysis liquid chromatography quadrupole time-of-flight mass spectrometry. Renal functions assessed by evaluating biochemical parameters oxidative stress parameters. Histopathological examinations conducted confirm damage. treatment attenuated significantly (p<0.05) urea, creatinine uric acid levels nephrotoxicity model Similarly, catalase kidney found have significant increase weight. Insignificant altered level glutathione superoxide dismutase observed histopathology showed that reduced tubular degeneration, interstitial infiltration inflammatory cells necrosis. Liquid spectrometry presence flavonoids, tannins, gallic tricarboxylic acid. μg/ml shown maximum radical scavenging which indicated concentration dependent activity. These results suggest weight, exhibits a potent nephroprotective effect on gentamicin-induced damage rats, may be due parameters, enzymes rats).